Tetrahydrofuranylmethylamines: An efficient and simple one??step synthesis and biological activities

M Limbeck, D Gündisch

Index: Limbeck, Marcus; Guendisch, Daniela Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 5 p. 895 - 900

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Citation Number: 5

Abstract

Abstract Various tetrahydrofuran-2-ylmethylamines have been prepared in good yields by an efficient one-step synthesis utilizing the reaction of tetrahydrofurfurylchloride with different secondary cyclic amines without any catalyst. The compounds were tested for their in vitro affinity for the (α4) 2 (β2) 3 and α7* nicotinic acetylcholine receptor (nAChR) subtypes. Pyrrolidine, piperidine and azepane containing analogs (1a, 1b, 1c) showed K i values in ...