7-Silylcamptothecins (silatecans): a new family of camptothecin antitumor agents

H Josien, D Bom, DP Curran, YH Zheng…

Index: Josien, Hubert; David, Bom; Curran, Dennis P.; Zheng, Yu-Huang; Chou, Ting-Chao Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 24 p. 3189 - 3194

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Citation Number: 73

Abstract

The synthesis and biological evaluation of about one dozen 7-silylcamptothecin derivatives are described. Most new compounds show potencies comparable to or better than camptothecin itself. The best compound, 11-fluoro-10-amino-7-trimethylsilylcamptothecin, is more than 20 times more potent than camptothecin in cell assays.

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