Synthesis of previously inaccessible quinazolines and 1, 4-benzodiazepines as potential anticonvulsants

…, NA Vaidya, WB Iturrian, CDW Blanton Jr

Index: Fatmi, Aqeel A.; Vaidya, Niteen A.; Iturrian, W. B.; Blanton, C. DeWitt Journal of Medicinal Chemistry, 1984 , vol. 27, # 6 p. 772 - 778

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Citation Number: 11

Abstract

A series of 4, 6, 7, 8-tetrasubstituted 3, 4-dihydroquinazolines, quinazolines, quinazolin-2- ones, 1, 2, 3; 4-tetrahydroquinazolin-2-ones, and 5, 7, 8, 9-tetrasubstituted 1, Cbenzodiazepines have been synthesized by utilizing the Diels-Alder reaction between furan o-amino nitriles and various alkyl or aryl vinyl ketone dienophiles to obtain the anthranilic acid precursors. All of the newly synthesized target compounds were evaluated ...