Synthesis and Anxiolytic Activity of 4-Amino-2, 6-dimethylnicotinic Acid Esters and Amides

…, LA Zhmurenko, VP Lezina, GM Molodavkin…

Index: Glozman; Zhmurenko; Lezina; Molodavkin; Voronina Pharmaceutical Chemistry Journal, 2001 , vol. 35, # 11 p. 591 - 593

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Abstract

The class of 2-and 4-aminopyridinecarboxylic acid derivatives contains compounds possessing anxiolytic, anticonvulsant, and antiamnesic activity [1–3]. This study was devoted to the search for new effective anxiolytics among 4-amino-2, 6-dimethylnicotinic acid esters and amides. In the first step, 4-chloro-2, 6-dimethylnicotinic acid ethylate (I)[4] reacted with the corresponding amines to yield 4-amino-2, 6-dimethylnicotinic acid ethyl esters (IIa–IIf, ...