Total synthesis of Amaryllidaceae pyrrolophenanthridinium alkaloids via the Ziegler-Ullmann reaction: Tortuosine, criasbetaine, and ungeremine

LM Stark, XF Lin, LA Flippin

Index: Stark, Lucy M.; Lin, Xiao-Fa; Flippin, Lee A. Journal of Organic Chemistry, 2000 , vol. 65, # 10 p. 3227 - 3230

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Citation Number: 37

Abstract

In connection with a program in our laboratory directed toward the total synthesis of pyrrolophenanthridinium alkaloids for antitumor screening, 2 we required a short and general approach to the Narcissus tortuosus constituent tortuosine, 1, 3 its structural relative criasbetaine, 2, 4 from Crinum asiaticum, and ungeremine, 3. 5 Structure-activity relationship (SAR) data for antitumor efficacy within the small class of known Amaryllidaceae ...