Tetrahedron letters

A solution to the component instability problem in the preparation of peptides containing C2-substituted cis-cyclobutane β-aminoacids: synthesis of a stable …

O Roy, S Faure, DJ Aitken

Index: Roy, Olivier; Faure, Sophie; Aitken, David J. Tetrahedron Letters, 2006 , vol. 47, # 33 p. 5981 - 5984

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Citation Number: 33

Abstract

Despite the inherent instability of C2-substituted cis-cyclobutane β-aminoacids, incorporation of such residues into peptides is shown to be possible through use of a 1- amino-2-(hydroxymethyl) cyclobutane derivative as a stable β-aminoacid surrogate. This synthetic strategy was validated by the synthesis of a rhodopeptin analogue.

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