Access to Di??and Trisubstituted Oxazoles by NBS??Mediated Oxidative Cyclisation of N??Acyl Amino Acid Derivatives
…, KK Viswanadham, P Sathyanarayana…
Index: Bathula, Surendar Reddy; Reddy, Muktapuram Prathap; Viswanadham, K. K. Durga Rao; Sathyanarayana, Pochampalli; Reddy, Maddi Sridhar European Journal of Organic Chemistry, 2013 , # 21 p. 4552 - 4557
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Citation Number: 8
Abstract
Abstract A remarkably simple method for the synthesis of di-and trisubstituted functionalised oxazoles under metal-and catalyst-free conditions is described. An iterative bromination and debromination of N-acylated amino acid derivatives with NBS as the sole reagent cleanly led to various substituted oxazoles.
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