Substituent activity relationship studies on new azolo benzoxazepinyl oxazolidinones

…, D Subrahmanyam, T Sastry, CP Narasimhulu…

Index: Das, Jagattaran; Sitaram Kumar; Subrahmanyam; Sastry; Prasad Narasimhulu; Laxman Rao; Kannan; Roshaiah; Awasthi, Riti; Patil, Santosh N.; Sarnaik; Rao Mamidi; Selvakumar; Iqbal, Javed Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 23 p. 8032 - 8042

Full Text: HTML

Citation Number: 13

Abstract

In an effort to discover potent antibacterials based on the entropically favored 'bioactive conformation'approach, a series of novel tricyclic molecules mimicking the conformationally constrained structure of Linezolid is reported. Based on the initial tricyclic molecule 1, the benzazepine derivative 2 was designed where the tricyclic structure had more flexibility around C–N bond compared to 1. While, the molecule 2 was less active, the molecule 3 ...