Approaches to the synthesis of some tyrosine-derived marine sponge metabolites: synthesis of verongamine and purealidin N

TR Boehlow, JJ Harburn…

Index: Wasserman, Harry H.; Wang, Jianji Journal of Organic Chemistry, 1998 , vol. 63, # 16 p. 5581 - 5586

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Citation Number: 96

Abstract

... Journal ... 11 and Wasserman. ... Purealidin N (28) was synthesized in a manner analogous to that used for verongamine (15). The MOM-protected oxime (23b) was reacted with histamine in MeOH at 60 °C for 72 h to give the corresponding amide (27) in an excellent yield of 96%. ...

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