Nitrobenzyl-based photosensitive phosphoramide mustards: Synthesis and photochemical properties of potential prodrugs for cancer therapy

R Reinhard, BF Schmidt

Index: Reinhard, Robert; Schmidt, Brigitte F. Journal of Organic Chemistry, 1998 , vol. 63, # 8 p. 2434 - 2441

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Citation Number: 32

Abstract

Several nitrobenzyl-based photosensitive phosphoramide mustards were synthesized. The nitrobenzyl moiety was structurally varied to find the most promising prodrug candidates in respect to photorelease and activity of the alkylating species. The synthesis of these compounds proved to be applicable even in regard to compounds with additional functionalization. The target molecules 13a, b to 14 exhibited the expected red shift in their ...