Sorting of Lipidated Peptides in Fluid Bilayers: A Molecular-Level Investigation

TA Daly, PF Almeida, SL Regen

Index: Daly, Trevor A.; Almeida, Paulo F.; Regen, Steven L. Journal of the American Chemical Society, 2012 , vol. 134, # 41 p. 17245 - 17252

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Citation Number: 8

Abstract

Nearest-neighbor recognition (NNR) measurements have been made for two lipidated forms of GlyCys, interacting with analogues of cholesterol and 1, 2-dipalmitoyl-sn-glycero-3- phosphocholine (DPPC) in the liquid-ordered (lo) and liquid-disordered (ld) phases. Interaction free energies that have been determined from these measurements have been used in Monte Carlo simulations to quantify the distribution of the peptides between liquid- ...