ERβ ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERβ selectivity
RE Mewshaw, RJ Edsall, C Yang…
Index: Journal of Medicinal Chemistry, , vol. 48, # 12 p. 3953 - 3979
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Citation Number: 127
Abstract
... Journal of Medicinal Chemistry. ... Finally, the 4-cyano derivative 62 was modified (Scheme 10) to afford the corresponding 4-substituted derivatives 68−72 by employing similar chemistry as previous shown in Scheme 7. figure Scheme 1 a. ...
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[Mewshaw, Richard E.; Edsall Jr., Richard J.; Yang, Cuijian; Manas, Eric S.; Xu, Zhang B.; Henderson, Ruth A.; Keith Jr., James C.; Harris, Heather A. Journal of Medicinal Chemistry, 2005 , vol. 48, # 12 p. 3953 - 3979]