Mass fragmentography of cortisol and cortisone: preliminary studies on the development of a reference method

HLJ Makin, DJH Trafford, NF Taylor

Index: Makin, Hugh L. J.; Trafford, David J. H.; Taylor, Norman F. Collection of Czechoslovak Chemical Communications, 2002 , vol. 67, # 1 p. 1 - 9

Full Text: HTML

Citation Number: 3

Abstract

Abstract Cortisol and cortisone are the two main glucocorticoids found in human plasma. Cortisol is commonly measured as a means of assessing adrenal function, usually by immunoassay, but such procedures must be subject to proper quality control which ideally uses analyte target values measured by isotope dilution mass fragmentography (GC-MS). Three derivatives of these steroids have been investigated for their chromatographic and ...