Tetrahedron

Solid and solution phase syntheses of the 2-cyanopyrrolidide DPP-IV inhibitor NVP-DPP728

N Willand, J Joossens, JC Gesquière, AL Tartar…

Index: Willand, Nicolas; Joossens, Jurgen; Gesquiere, Jean-Claude; Tartar, Andre L; Evans, D.Michael; Roe, Michael B Tetrahedron, 2002 , vol. 58, # 28 p. 5741 - 5746

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Citation Number: 5

Abstract

DPP-IV inhibitors have been suggested as potential new treatments for type-II diabetes and 2-cyanopyrrolidides have been reported as potent DPP-IV inhibitors. Alternative synthetic approaches to one such compound, NVP-DPP728, are investigated here. One strategy is based in solution phase and is amenable to scale-up. The other is based on solid phase and is appropriate for the rapid analoging of the structural series.

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