Improved specific radioactivity of the PET radioligand [11C] FLB 457 by use of the GE Medical Systems PETtrace MeI MicroLab

J Sandell, O Langer, P Larsen, F Dolle…

Index: Sandell, Johan; Langer, Oliver; Larsen, Peter; Dolle, Frederic; Vaufrey, Francoise; Demphel, Stephane; Crouzel, Christian; Halldin, Christer Journal of Labelled Compounds and Radiopharmaceuticals, 2000 , vol. 43, # 4 p. 331 - 338

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Citation Number: 55

Abstract

Abstract [11 C] FLB 457 is a high affinity dopamine D 2 receptor radioligand that is used for visualisation and quantitation of extrastriatal dopamine D 2 receptors with positron emission tomography (PET). In this study, we report a comparison regarding the specific radioactivity of [11 C] FLB 457 obtained by two different methods of synthesising [11 C] methyl iodide. In addition, the synthesis of unlabelled FLB 457 and the corresponding desmethyl-precursor, ...

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