A PRACTICAL LARGE-SCALE PREPARATION OF 5'-BROMOSPIRO (CYCLOHEXANE-1, 3-[3H] INDOL)-2'(1'H)-ONE

BK Wilk, A Rubezhov, JL Helorn…

Index: Organic Preparations and Procedures International, , vol. 37, # 3 p. 283 - 285

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Abstract

... The dark red, organic layer was washed with brine (250 mL) and transferred to a 5-L distillation ... dibromo- and 1,5-diiodopentane were tried with no apparent improvement in the yield and the purification procedure. ... We found this method impractical for a large-scale preparation. ...

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A PRACTICAL LARGE-SCALE PREPARATION OF 5'-BROMOSPIRO (CYCLOHEXANE-1, 3-[3H] INDOL)-2'(1'H)-ONE

[Wilk, Bogdan K.; Rubezhov, Arkadiy; Helom, Jean L.; Routel, Lisa R.; Potoski, John R. Organic Preparations and Procedures International, 2005 , vol. 37, # 3 p. 283 - 285]

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