Journal of the American Chemical Society

Stereochemical course of. gamma. replacement on an amino acid substrate in a pyridoxal phosphate dependent enzymic reaction

MNT Chang, C Walsh

Index: Chang, Michael N. T.; Walsh, Christopher Journal of the American Chemical Society, 1980 , vol. 102, # 24 p. 7368 - 7370

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Citation Number: 17

Abstract

Pyridoxal-P (PLP) is an obligate cofactor for a variety of enzyme-catalyzed transformations at the a,@, y, or o carbons of amino acid substrates by facilitated formation of stabilized substrate carbanion intermediates in catalysis. The subset of enzymes catalyzing y replacement of a potentially good leaving group Y by an alternate nucleophile Y'(eq l), a formal substitution at an unactivated carbon, in fact acts via sequential for-mation of a and ...