Synthesis and dihydropteridine reductase inhibitory effects of potential metabolites of the neurotoxin 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine

W Gessner, A Brossi, RS Shen…

Index: Gessner, Wieslaw; Brossi, Arnold; Shen, Rong-sen; Abell, Creed W. Journal of Medicinal Chemistry, 1985 , vol. 28, # 3 p. 311 - 317

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Citation Number: 34

Abstract

Medicinal Chemistry Section, Laboratory of Chemistry, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20205, and Department of Human Biological Chemistry and Genetics, Division of Biochemistry, The University of Texas Medical Branch, Galveston, Texas 77550. Received July 2, 1984 l-Methyl-4-phenyl-l, 2, 3, 6-tetrahydropyridine (MPTP) is a nigrostriatal ...