Reactivity of molecular oxygen with ethoxycarbonyl derivatives of tetrathiatriarylmethyl radicals

…, FA Villamena, CM Hadad, P Kuppusamy…

Index: Xia, Shijing; Villamena, Frederick A.; Hadad, Christopher M.; Kuppusamy, Periannan; Li, Yunbo; Zhu, Hong; Zweier, Jay L. Journal of Organic Chemistry, 2006 , vol. 71, # 19 p. 7268 - 7279

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Citation Number: 36

Abstract

Tetrathiatriarylmethyl (TAM) radicals are commonly used as oximetry probes for electron paramagnetic resonance imaging applications. In this study, the electronic properties and the thermodynamic preferences for O2 addition to various TAM-type triarylmethyl (trityl) radicals were theoretically investigated. The radicals' stability in the presence of O2 and biological milieu was also experimentally assessed using EPR spectroscopy. Results ...