Antitumor agents XLII: Comparison of antileukemic activity of helenalin, brusatol, and bruceantin and their esters on different strains of p??388 lymphocytic leukemic …

…, D Sims, T Ibuka, YF Liou, Y Imakura

Index: Hall; Lee; Okano; Sims; Ibuka; Liou; Imakura Journal of Pharmaceutical Sciences, 1981 , vol. 70, # 10 p. 1147 - 1150

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Citation Number: 29

Abstract

Abstract Based on the fact that some known antineoplastic agents possess an ester moiety within their structure, the esters of helenalin, a sesquiterpene lactone, and of brusatol and bruceantin, quassinoids, were synthesized and tested for antileukemic activity in the P-388 screen. These agents gave different T/C% values dependent on the P-388 lymphocytic leukemia strain and the host strain of mice used. Later studies demonstrated that the ...