Total synthesis and anti-leishmanial activity of some curcumin analogues

DCF Gomes, LV Alegrioa, LL Leon…

Index: De Castro Ferreira Gomes, Denise; Alegrio, Leila Vilela; Leon, Leonor L.; De Lima, Marco Edilson Freire Arzneimittel-Forschung/Drug Research, 2002 , vol. 52, # 9 p. 695 - 698

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Citation Number: 29

Abstract

Summary Curcumin (1) an important yellow dye isolated from Curcuma longa rhizomes, exhibits a variety of pharmacological effects such as anti-inflammatory, antioxidant and antiviral activity. Ten curcuminoids (2–11) were synthesized by the condensation of 2, 4- pentanedione with differently substituted benzaldehydes, using the boron complex approach, which avoided Knoevenagel condensation at C-3 of the diketone. The ...

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