Molecules

Design, synthesis and anti-HIV integrase evaluation of 4-oxo-4H-quinolizine-3-carboxylic acid derivatives

YS Xu, CC Zeng, ZG Jiao, LM Hu, R Zhong

Index: Xu, Yi-Sheng; Zeng, Cheng-Chu; Jiao, Zi-Guo; Hu, Li-Ming; Zhong, Ru-Gang Molecules, 2009 , vol. 14, # 2 p. 868 - 883

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Citation Number: 25

Abstract

Human immunodeficiency virus type 1 (HIV-1) is the major pathogen of the infection of acquired immunodeficiency syndrome (AIDS) [1]. In the past two and half decades, various compounds have been developed as medicinal candidates for the treatment of HIV infections aiming at one or several steps of the HIV-1 life cycle [2,3,4,5] such as absorption, entry, fusion, un-coating, reverse transcription, integration, transcription and maturation. Owing to the facts that HIV ...