Biotin Sulfone as a New Tool for Synthetic Oligosaccharide Immobilization: Application to Multiple Analysis Profiling and Surface Plasmonic Analysis of Anti-Candida …

…, C Savaux, A Standaert-Vitse, M Tabouret…

Index: Collot, Mayeul; Sendid, Boualem; Fievez, Aurelie; Savaux, Camille; Standaert-Vitse, Annie; Tabouret, Marc; Drucbert, Anne Sophie; Danze, Pierre Marie; Poulain, Daniel; Mallet, Jean-Maurice Journal of Medicinal Chemistry, 2008 , vol. 51, # 19 p. 6201 - 6210

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Citation Number: 22

Abstract

As a part of our glycoantigen synthetic program for diagnosis and basic analysis of yeast- related pathogenic mechanisms, a library of 1→ 2 oligomannosides suitable for immunoanalysis was prepared. The use of biotin sulfone, an oxidized form of biotin, offers a convenient solution for both oligosaccharide synthesis and immobilization on microspheres and surface plasmon resonance sensors. The application of this new strategy for the ...