Activation for Catalysis of Penicillin-Binding Protein 2a from Methicillin-Resistant Staphylococcus a ureus by Bacterial Cell Wall

…, M Lee, K Morio, T Nowak, S Mobashery

Index: Fuda, Cosimo; Hesek, Dusan; Lee, Mijoon; Morio, Ken-Ichiro; Nowak, Thomas; Mobashery, Shahriar Journal of the American Chemical Society, 2005 , vol. 127, # 7 p. 2056 - 2057

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Citation Number: 52

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) has acquired a unique penicillin- binding protein (PBP), PBP 2a, which has rendered the organism resistant to the action of all available β-lactam antibiotics. The X-ray structure of PBP 2a shows the active site in a closed conformation, consistent with resistance to inhibition by β-lactam antibiotics. However, it is known that PBP 2a avidly cross-links the S. aureus cell wall, which is its ...

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