2-Pyridon-1-yl diphenyl phosphate. A useful new reagent for the synthesis of amides and peptides

S Kim, SS Kim

Index: Kim, Sunggak; Kim, Sung Soo Journal of the Chemical Society, Chemical Communications, 1986 , # 9 p. 719

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Abstract

2-Pyridon-1-yl diphenyl phosphate is found to be a useful coupling agent for the synthesis of amides and practically race m iza tion -fr ee pe pt id es . ... Among a large number of coupling agents for peptide synthesis,' phosphorus-based coupling agents have attracted a great deal of recent attention.2 In the course of our work in developing new effective coupling agents,3 we have found that 2-pyridon-1-yl diphenyl phosphate is easily prepared by simply mixing ...

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