Straightforward Strategy for the Stereoselective Synthesis of Spiro??Fused (C??5) Isoxazolino??or (C??3) Pyrazolino??(C??3) quinolin??2??ones from Baylis–Hillman Adducts …

V Singh, V Singh, S Batra

Index: Singh, Virender; Singh, Vijay; Batra, Sanjay European Journal of Organic Chemistry, 2008 , # 32 p. 5446 - 5460

Full Text: HTML

Citation Number: 11

Abstract

Abstract A straightforward and general approach for the stereoselective synthesis of spiro- fused (C-5) isoxazolino-or (C-3) pyrazolino-(C-3) quinolin-2-ones from the adducts offorded from the Baylis–Hillman reaction of 2-nitrobenzaldehyde and ethyl acrylate by sequential 1, 3-dipolar cycloaddition and reductive cyclization is presented. It was found that the reductive cyclization of the isoxazoline derivatives proceeded efficiently in the presence of In/HCl, ...