Tetrahedron

Carbon based nucleophilic ring opening of activated monocyclic β-lactams; Synthesis and stereochemical assignment of the ACE inhibitor WF-10129

JE Baldwin, RM Adlington, AT Russell, ML Smith

Index: Baldwin, Jack E.; Adlington, Robert M.; Russell, Andrew T.; Smith, Marie L. Tetrahedron, 1995 , vol. 51, # 16 p. 4733 - 4762

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Citation Number: 23

Abstract

The preparation of γ-keto α-amino acids via carbon based nucleophilic ring opening of activated monocyclic β-lactams was examined and applied to the synthesis and stereochemical assignment of the dipeptide angiotensin converting enzyme (ACE) inhibitor, WF-10129.