Microwave-assisted synthesis of isonitriles: a general simple methodology

A Porcheddu, G Giacomelli…

Index: Porcheddu, Andrea; Giacomelli, Giampaolo; Salaris, Margherita Journal of Organic Chemistry, 2005 , vol. 70, # 6 p. 2361 - 2363

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Citation Number: 75

Abstract

There are several methods reported for isonitrile synthesis, by dehydration of formamides with various reagents, 6 using chlorodimethylformiminium chloride, 7 phosphoryl chloride, 8 phosgene 9 or diphosgene, 10 DABCO, 11 aryl chlorothionoformate, 12 and supported sulfonyl chlorides under microwave irradiation. 13 Unfortunately, most of these methods have limited utility and applicability due to the extreme toxicity and cumbersome handling, and high costs in the ...