Combined Directed ortho Metalation− Halogen Dance (HD) Synthetic Strategies. HD− Anionic ortho Fries Rearrangement and Double HD Sequences

…, T Rantanen, KA Ogilvie, U Groth, V Snieckus

Index: Miller, Ricarda E.; Rantanen, Toni; Ogilvie, Kevin A.; Groth, Ulrich; Snieckus, Victor Organic Letters, 2010 , vol. 12, # 10 p. 2198 - 2201

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Citation Number: 28

Abstract

A general and efficient directed ortho metalation (D o M)− halogen dance (HD)− electrophile quench sequence for the synthesis of trisubstituted pyridyl O-carbamates is described. A second HD sequence furnishes highly functionalized tetrasubstituted pyridines. ...