Unnatural multidentate metal ligating α-amino acids

CM Micklitsch, Q Yu, JP Schneider

Index: Micklitsch, Christopher M.; Yu, Qian; Schneider, Joel P. Tetrahedron Letters, 2006 , vol. 47, # 35 p. 6277 - 6280

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Citation Number: 16

Abstract

A family of penta-and hexadentate metal ligating α-amino acids, suitably protected for Fmoc solid-phase chemistry, has been prepared. These residues incorporate the mono-amides of ethanolaminetriacetic acid, ethylenediaminetriacetic acid, and ethylenediaminetetraacetic acid as side chains. Side chains are tethered varying distances (n) from the Cα-carbon to allow metal binding events to occur at distinct distances from the peptide backbone. These ...