Efficient synthesis of 1β-O-acyl glucuronides via selective acylation of allyl or benzyl D-glucuronate

ER Bowkett, JR Harding, JL Maggs, BK Park, JA Perrie…

Index: Bowkett, Elizabeth R.; Harding, John R.; Maggs, James L.; Park, B. Kevin; Perrie, Jennifer A.; Stachulski, Andrew V. Tetrahedron, 2007 , vol. 63, # 32 p. 7596 - 7605

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Citation Number: 30

Abstract

Acyl glucuronides are key metabolites for many carboxylic acid-containing drugs, notably those of the non-steroidal anti-inflammatory class. In the processes of drug safety assessment and new drug development, it is essential that acyl glucuronides, if formed in vivo, should be made conveniently available for bioevaluation. We recently showed that selective acylation of allyl glucuronate is a promising method for the synthesis of these ...