Bioorganic chemistry

A second-generation copper (II)-mediated metallo-DNA-base pair

N Zimmermann, E Meggers, PG Schultz

Index: Zimmermann, Nicole; Meggers, Eric; Schultz, Peter G. Bioorganic Chemistry, 2004 , vol. 32, # 1 p. 13 - 25

Full Text: HTML

Citation Number: 75

Abstract

Metal-dependent pairing of nucleobases represents an alternative DNA base pairing scheme. Our first-generation copper (II)-mediated pyridine-2, 6-dicarboxylate (Dipic) and pyridine (Py) metallo-base pair has a stability comparable to the natural base pairs dA: dT and dC: dG but does not have the selectivity of the Watson Crick base pairs. In order to increase the selectivity of base pair formation, a second-generation metallo-base pair was ...