New base pairing motifs. The synthesis and thermal stability of oligodeoxynucleotides containing imidazopyridopyrimidine nucleosides with the ability to form four …

…, A Kiyosue, N Atsumi, Y Ueno, A Matsuda

Index: Minakawa, Noriaki; Kojima, Naoshi; Hikishima, Sadao; Sasaki, Takashi; Kiyosue, Arihiro; Atsumi, Naoko; Ueno, Yoshihito; Matsuda, Akira Journal of the American Chemical Society, 2003 , vol. 125, # 33 p. 9970 - 9982

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Citation Number: 102

Abstract

The synthesis and thermal stability of oligodeoxynucleotides (ODNs) containing imidazo [5', 4': 4, 5] pyrido [2, 3-d] pyrimidine nucleosides 1-4 (NN, OO, NO, and ON, respectively) with the aim of developing two sets of new base pairing motifs consisting of four hydrogen bonds (H-bonds) is described. The proposed four tricyclic nucleosides 1-4 were synthesized through the Stille coupling reaction of a 5-iodoimidazole nucleoside with an appropriate 5- ...