Synlett

Acid-mediated halogen exchange in heterocyclic arenes: A highly effective iodination method

C Wolf, GE Tumambac, CN Villalobos

Index: Wolf, Christian; Tumambac, Gilbert E.; Villalobos, Cristina N. Synlett, 2003 , # 12 p. 1801 - 1804

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Citation Number: 11

Abstract

Abstract Heterocyclic arenes including pyridyl, quinolyl, and isoquinolyl chlorides have been converted to their corresponding iodides in good to high yields via acid-mediated nucleophilic halogen exchange with sodium iodide. This procedure avoids the use of transition metals, harsh reaction conditions, and affords highly regioselective halide exchange. Chloride substituents in position 2 and 4 of pyridines and quinolines are ...

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