New synthesis of the cyclic tetrapeptide tentoxin employing an azlactone as key intermediate

F Cavelier, J Verducci

Index: Cavelier, Florine; Verducci, Jean Tetrahedron Letters, 1995 , vol. 36, # 25 p. 4425 - 4428

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Citation Number: 42

Abstract

An improved preparation of the cyclic tetrapeptide Tentoxin is reported employing an azlactone as key intermediate. This new synthetic route offers the advantage over existing methodologies that the dehydro amino acid would easily be varied, thus allowing the simple preparation of analogues.