Synthesis and antimycobacterial properties of N-substituted 6-amino-5-cyanopyrazine-2-carboxamides

…, M Dolezal, M Svobodova, M Vejsova, J Kunes…

Index: Zitko, Jan; Dolezal, Martin; Svobodova, Michaela; Vejsova, Marcela; Kunes, Jiri; Kucera, Radim; Jilek, Petr Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 4 p. 1471 - 1476

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Citation Number: 21

Abstract

A series of fifteen new compounds related to pyrazinamide (PZA) were synthesized, characterized with analytical data and screened for antimycobacterial, antifungal and antibacterial activity. The series consists of 6-chloro-5-cyanopyrazine-2-carboxamide and N- substituted 6-amino-5-cyanopyrazine-2-carboxamides, derived from the previous by nucleophilic substitution with various non-aromatic amines (alkylamines, cycloalkylamines ...

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