Studies on quinones. Part 47. Synthesis of novel phenylaminophenanthridinequinones as potential antitumor agents

JA Valderrama, A Ibacache, JA Rodriguez…

Index: Valderrama, Jaime A.; Ibacache, Andrea; Rodriguez, Jaime A.; Theoduloz, Cristina; Benites, Julio European Journal of Medicinal Chemistry, 2011 , vol. 46, # 8 p. 3398 - 3409

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Citation Number: 16

Abstract

Abstract In our search for potential anticancer agents, a series of 8-and 9-phenylamino-3, 4- tetrahydro-phenanthridine-1, 7, 10 (2H)-triones with substituent variations at 6-, 8-and 9- positions were prepared using a highly efficient sequence involving: a) solar photoacylation reactions of benzoquinone with arylaldehydes, b) one-pot procedure for the synthesis of 3, 4- dihydrophenanthridine-1, 7, 10 (2H)-trione intermediates from acylhydroquinones and c) ...

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