Potential antipsoriatic avarol derivatives as antioxidants and inhibitors of PGE2 generation and proliferation in the HaCaT cell line
M Amigó, MC Terencio, M Mitova, C Iodice…
Index: Amigo, Maria; Terencio, Maria Carmen; Mitova, Maya; Iodice, Carmine; Paya, Miguel; De Rosa, Salvatore Journal of Natural Products, 2004 , vol. 67, # 9 p. 1459 - 1463
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Citation Number: 26
Abstract
The synthesis and structure-activity relationships for a series of 14 new avarol derivatives as antioxidants and inhibitors of cell proliferation and PGE2 generation in human keratinocytes are described. Compound 6 (thiosalicylic derivative) was the most potent inhibitor of superoxide generation in human neutrophils and also potently inhibited PGE2 generation in the human keratinocyte HaCaT cell line. Compound 7 (3'-methylaminoavarone) presented ...
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