Synthesis and antitumor activity of 5-[1-(3-(dimethylamino) propyl)-5-halogenated-2-oxoindolin-(3Z)-ylidenemethyl]-2, 4-dimethyl-1H-pyrrole-3-carboxamides

K Lv, LL Wang, ML Liu, XB Zhou, SY Fan, HY Liu…

Index: Lv, Kai; Wang, Li-Li; Liu, Ming-Liang; Zhou, Xin-Bo; Fan, Shi-Yong; Liu, Hong-Ying; Zheng, Zhi-Bing; Li, Song Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 10 p. 3062 - 3065

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Citation Number: 16

Abstract

We report herein the design and synthesis of novel 1-[3-(dimethylamino) propyl] indolin-2- one derivatives based on the structural features of Sunitinib, a known multitargeted receptor tyrosine kinase inhibitor, and TMP-20, a previously discovered compound with good antitumor activity in our lab. These newly synthesized derivatives were evaluated for in vitro activity against five human cancer cell lines and VEGF/bFGF-stimulated HUVECs. Results ...