Synthesis of (+)??Dumetorine and Congeners by Using Flow Chemistry Technologies

…, A Rencurosi, S Gagliardi, D Passarella…

Index: Riva, Elena; Rencurosi, Anna; Gagliardi, Stefania; Passarella, Daniele; Martinelli, Marisa Chemistry - A European Journal, 2011 , vol. 17, # 22 p. 6221 - 6226

Full Text: HTML

Citation Number: 31

Abstract

Abstract An efficient total synthesis of the natural alkaloid (+)-dumetorine by using flow technology is described. The process entailed five separate steps starting from the enantiopure (S)-2-(piperidin-2-yl) ethanol 4 with 29% overall yield. Most of the reactions were carried out by exploiting solvent superheating and by using packed columns of immobilized reagents or scavengers to minimize handling. New protocols for performing ...