The Journal of organic chemistry

One-pot in situ formation and reaction of trimethyl (trichloromethyl) silane: application to the synthesis of 2, 2, 2-trichloromethylcarbinols

KE Henegar, R Lira

Index: Henegar, Kevin E.; Lira, Ricardo Journal of Organic Chemistry, 2012 , vol. 77, # 6 p. 2999 - 3004

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Citation Number: 14

Abstract

2, 2, 2-Trichloromethylcarbinols are 1 are valuable synthetic intermediates with a multitude of uses. A scalable procedure for the synthesis of TMS-protected-2, 2, 2- trichloromethylcarbinols and 2, 2, 2-trichloromethylcarbinols 1 was developed that employs the in situ generation and reaction of trimethyl (trichloromethyl) silane (CCl3-TMS). The procedure avoids the exposure of the carbonyl compounds to the strongly basic ...

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