Tetrahedron letters

Bromodimethylsulfonium bromide mediated Michael addition of amines to electron deficient alkenes

AT Khan, T Parvin, S Gazi, LH Choudhury

Index: Khan, Abu T.; Parvin, Tasneem; Gazi, Sarifuddin; Choudhury, Lokman H. Tetrahedron Letters, 2007 , vol. 48, # 22 p. 3805 - 3808

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Citation Number: 45

Abstract

Bromodimethylsulfonium bromide has been found to be an efficient catalyst for the Michael addition of a wide variety of amines to electron deficient alkenes at room temperature. The protocol is very simple and chemoselective. Aliphatic and benzylic amines undergo conjugate addition within a very short period under solvent-free conditions and provide excellent yields of products.

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