Journal of medicinal chemistry

Cardenolide analogs. 7. Synthesis and biological activity of some new steroidal guanylhydrazones

A Gelbart, R Thomas

Index: Gelbart,A.; Thomas,R. Journal of Medicinal Chemistry, 1978 , vol. 21, p. 284 - 288

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Citation Number: 24

Abstract

The synthesis, proof of structure, and biological activity of some new steroidal 17P-formyl guanylhydrazones are described. The guanylhydrazones of nondigitalis-like steroids inhibited myocardial Na+, K+-ATPase but had only a depressant effect on myocardial contractility. By comparison, the corresponding guanylhydrazone of a digitalis-like steroid gave a positive inotropic effect in concentrations that also inhibited Na+, K'-ATPase. The ...