Pyrimido-oxazepine as a versatile template for the development of inhibitors of specific kinases

…, DL Milligan, J Columbus, YR Hadari, P Kussie…

Index: Pan, Weitao; Liu, Hu; Xu, Yong-Jiang; Chen, Xin; Kim, Ki Hwan; Milligan, Daniel L.; Columbus, John; Hadari, Yaron R.; Kussie, Paul; Wong, Wai C.; Labelle, Marc Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 24 p. 5474 - 5477

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Citation Number: 20

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Pyrimido-oxazepine based sub-micromolar inhibitors (2–4) for Aurora and FLT-3 were designed and synthesized. These preliminary results supported the potential use of pyrimido-oxazepines as a versatile template for developing specific kinase inhibitors. ... The development of ...