Organic letters

Highly chemo-and enantioselective synthesis of 3-Allyl-3-aryl oxindoles via the direct palladium-catalyzed α-arylation of amides

X Luan, L Wu, E Drinkel, R Mariz, M Gatti…

Index: Luan, Xinjun; Wu, Linglin; Drinkel, Emma; Mariz, Ronaldo; Gatti, Michele; Dorta, Reto Organic Letters, 2010 , vol. 12, # 9 p. 1912 - 1915

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Citation Number: 60

Abstract

A new NHC· Pd-catalyzed asymmetric α-arylation of amides is reported that gives direct access to synthetically valuable, allylated oxindoles with quaternary carbon centers. The reaction is made possible by the introduction of a new chiral NHC ligand. The palladium complexes derived therefrom combine excellent reactivity with high chemo-and enantioselectivity for the title transformation.

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