Synthesis

A Facile Synthesis of Fulgenic Acid via Base Induced 1, 4-Dehydrobromination of (Bromomethyl) methylmaleic Anhydride

SG Deshpande, NP Argade

Index: Deshpande, Sachin G.; Argade, Narshinha P. Synthesis, 1999 , # 8 p. 1306 - 1308

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Citation Number: 9

Abstract

Abstract: A facile synthesis of fulgenic acid (1) via 1, 4-dehydrobromination of (bromomethyl) methylmaleic anhydride (2) using aqueous KOH, t-BuOK in THF, and NaH in benzene in 60– 85% yield is described. The newly synthesized (hydroxymethyl) methylmaleic anhydride (3) also underwent smooth 1, 4-elimination in the presence of aqueous KOH to yield 1. Key words:(bromomethyl) methylmaleic anhydride, base, 1, 4-elimination, fulgenic acid

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