A facile and practical one-pot synthesis of multisubstituted 2-aminothiophenes via imidazole-catalyzed Gewald reaction

XG Huang, J Liu, J Ren, T Wang, W Chen, BB Zeng

Index: Huang, Xian-Gui; Liu, Jia; Ren, Jiangmeng; Wang, Tao; Chen, Weidong; Zeng, Bu-Bing Tetrahedron, 2011 , vol. 67, # 34 p. 6202 - 6205

Full Text: HTML

Citation Number: 44

Abstract

A simple and efficient procedure was developed for the synthesis of multisubstituted 2- aminothiophene derivatives. In the presence of catalytic amount of imidazole, ketones or aldehydes, dicyanomethane and elemental sulfur were converted into the corresponding 2- aminothiophene derivatives in moderate to high yields in DMF at 60° C.