Tetrahedron letters

Microwave-assisted cleavage of phosphate, phosphonate and phosphoramide esters

GDK Kumar, D Saenz, GL Lokesh, A Natarajan

Index: Kishore Kumar; Saenz, David; Lokesh; Natarajan, Amarnath Tetrahedron Letters, 2006 , vol. 47, # 35 p. 6281 - 6284

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Citation Number: 30

Abstract

Phosphorylation of proteins among other things facilitates protein–protein interactions that are important for a variety of cellular functions, including cell division. 1 Therefore, phosphate mimics viz., phosphonates and phosphoramides are valuable chemical tools to probe cellular functions. 2 For example, sphingosine-1-phosphate, is a suspect in a plethora of diseases states. 3 Due to the metabolic lability of the phosphate group on ...