Chemical Communications

One-pot approach for the synthesis of trans-cyclopropyl compounds from aldehydes. Application to the synthesis of GPR40 receptor agonists

M Davi, H Lebel

Index: Davi, Michael; Lebel, Helene Chemical Communications, 2008 , # 40 p. 4974 - 4976

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Citation Number: 7

Abstract

Recently, Taylor et al. have developed a tandem oxidation process that allows access to polysubstituted cyclopropanes from alcohols or α-hydroxyketones using stoichiometric phosphorus- and sulfur-ylides as reactants. 7 However, to the best of our knowledge, there is no report of a catalytic one-pot process providing cyclopropyl compounds from aldehydesvia the cyclopropanation of an alkene. In this communication, we now report a novel one-pot process to synthesize ...

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