Improved methods for the synthesis of porphyrin alcohols and aldehydes from protoporphyrin IX dimethyl ester and their further modification

SB Kahl, JJ Schaeck, MS Koo

Index: Kahl, Stephen B.; Schaeck, John J.; Koo, Myoung-Seo Journal of Organic Chemistry, 1997 , vol. 62, # 6 p. 1875 - 1880

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Citation Number: 26

Abstract

Organic synthetic transformations involving functional groups attached to the periphery of the porphyrin macrocycle have occupied chemists for the past 65 years since Fischer reported the first total synthesis of protoheme. 1, 2 Such transformations have recently taken on added significance through the use of porphyrin alcohols and aldehydes as intermediates in the preparation of compounds with potential uses in binary therapeutic ...